Therapy Detail

Therapy Name BI 894999
Synonyms
Therapy Description

BI 894999 is a bromodomain (BET) inhibitor with selective activity against BRD2/3/4 and BRDT, which may result in G1 arrest and apoptosis, and inhibition of tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B79).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BI 894999 BET Inhibitor (Pan) 25 BI 894999 is a bromodomain (BET) inhibitor with selective activity against BRD2/3/4 and BRDT, which may result in G1 arrest and apoptosis, and inhibition of tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B79).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable BI 894999 Phase I Actionable In a Phase I trial, treatment with BI 894999 resulted in stable disease in one patient and a partial response in three patients of 27 evaluable patients with advanced solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2504)). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02516553 Phase I BI 894999 BI 894999 First in Human Dose Finding Study in Advanced Malignancies Recruiting


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