Therapy Detail
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| Therapy Name | TAS4464 |
| Synonyms | |
| Therapy Description |
TAS4464 inhibits NEDD8 activating enzyme (NAE), therefore inhibits tumor cell growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C176). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TAS4464 | TAS4464 inhibits NEDD8 activating enzyme (NAE), therefore inhibits tumor cell growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C176). |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | hematologic cancer | not applicable | TAS4464 | Preclinical - Cell culture | Actionable | In a preclinical study, TAS4464 demonstrated cytotoxicity in a number of hematologic cancer cell lines in culture (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C176). | detail... |
| Unknown unknown | multiple myeloma | not applicable | TAS4464 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TAS4464 inhibited growth and induced apoptosis in multiple myeloma cell lines in culture, resulted in tumor suppression in cell line xenograft models (Cancer Res 2015;75(15 Suppl):Abstract nr 1730). | detail... |
| Unknown unknown | acute lymphoblastic leukemia | not applicable | TAS4464 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TAS4464 resulted in complete tumor regression in cell line xenograft models of acute lymphocytic leukemia (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C176). | detail... |
| Unknown unknown | clear cell sarcoma | not applicable | TAS4464 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TAS4464 inhibited growth and induced apoptosis in clear cell carcinoma cell lines in culture, resulted in tumor suppression in cell line xenograft models (Cancer Res 2016;76(14 Suppl):Abstract nr 3777). | detail... |
| Unknown unknown | rhabdomyosarcoma | not applicable | TAS4464 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TAS4464 inhibited growth and induced apoptosis in rhabdomyosarcoma cell lines in culture, resulted in tumor suppression in cell line xenograft models (Cancer Res 2016;76(14 Suppl):Abstract nr 3777). | detail... |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
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- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT02978235 | Phase Ib/II | TAS4464 | A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma | Terminated |
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