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|Therapy Name||Osimertinib + PF-573228 + Saracatinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 24||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|PF-573228||PF-573,228|PF573228|PF 573228||FAK inhibitor 15||PF-573228 is a small molecule inhibitor of PTK2 (FAK), which may reduce cell migration and decrease focal adhesion cellular turnover, thus suppressing metastasis (PMID: 17395594, PMID: 30352800, PMID: 32349327).|
|Saracatinib||AZD0530||BCR-ABL Inhibitor 29 SRC Inhibitor 31||Saracatinib (AZD0530) is a multi-kinase inhibitor with activity against ABL and SRC, which may block proliferation, metastasis, and survival in cancer cells (PMID: 19393585, PMID: 32398945).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|