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|Therapy Name||Seribantumab + XL147|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Seribantumab||MM-121|SAR256212||HER3 (ERBB3) Antibody 14||Seribantumab (SAR256212) is a human monoclonal antibody that binds ERBB3 (HER3) and prevents ligand binding and heterodimerization with other ERBB family members, resulting in decreased activation of downstream signaling and potentially leading to reduced tumor growth (PMID: 26310543, PMID: 30975923).|
|XL147||SAR245408|Pilaralisib||PI3K Inhibitor (Pan) 37||Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Seribantumab + XL147||Phase Ib/II||Actionable||In a Phase Ib trial, treatment with the combination of Pilaralisib (SAR245408, XL147) and Seribantumab (SAR256212) resulted in stable disease as best response in 52.2% (12/23) patients with advanced solid tumors, with no difference in response between patients harboring PIK3CA mutations and those with wild-type PIK3CA (PMID: 28031425).||28031425|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|