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Therapy Name | Tinostamustine |
Synonyms | |
Therapy Description |
Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Tinostamustine | EDO-S101|EDOS101|EDO S101 | Chemotherapy - Alkylating 16 HDAC Inhibitor 42 | Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02576496 | Phase I | Tinostamustine | Study of EDO-S101, A First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies | Recruiting | USA | ITA | FRA | ESP | DEU | 2 |
NCT03452930 | Phase I | Tinostamustine | Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma | Active, not recruiting | USA | 0 |
NCT05432375 | Phase I | Tinostamustine | Study of Tinostamustine for Adjuvant Treatment of Glioblastoma | Recruiting | ESP | 1 |
NCT03345485 | Phase Ib/II | Tinostamustine | Study of the Safety, Pharmacokinetics and Efficacy of EDO-S101, in Patients With Advanced Solid Tumors | Unknown status | USA | CAN | 0 |
NCT03687125 | Phase Ib/II | Tinostamustine | Tinostamustine Conditioning and Autologous Stem Cell (TITANIUM1) | Terminated | USA | 2 |