Therapy Detail

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Therapy Name NOX66
Synonyms
Therapy Description

NOX66 is a suppository formulation of idronoxil, which leads to inhibition of PI3K/Akt signaling via blockade of ENOX2, thereby potentially increasing the sensitivity of cancer cells to chemotherapeutics (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NOX66 NOX 66|NOX-66 NOX66 is a suppository formulation of idronoxil, which inhibits PI3K/Akt signaling via blockade of ENOX2, thereby potentially increasing the sensitivity of cancer cells to chemotherapeutics (PMID: 34306271).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04957290 Phase Ib/II NOX66 A Study of NOX66 and External Beam Radiotherapy in Patients With Metastatic Castration-resistant Prostate Cancer and Other Solid Tumors Recruiting USA 0
NCT05100628 Phase I NOX66 Doxorubicin + NOX66 A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma Recruiting USA 0


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