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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|RX-5902||CTNNB1 Inhibitor 26||RX-5902 binds to and inhibits Ddx5, which in turn inhibits beta-catenin signaling, results in down-regulation of gene expression and tumor cell growth inhibition (PMID: 25649741, PMID: 31488700).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||RX-5902||Phase I||Actionable||In a Phase I trial, RX-5902 treatment resulted in stable disease in 43% (15/35) of patients with advanced solid tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 258P; NCT02003092).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02003092||Phase I||RX-5902||RX-5902 Treatment of Subjects With Solid Tumors||Terminated|