Therapy Detail

Therapy Name BI 754091 + BI 891065
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BI 754091 Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 48 BI 754091 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (J Clin Oncol. 36, no. 5_suppl (February 2018) 212-212).
BI 891065 SMAC Mimetic 8 BI 891065 is a SMAC mimetic, which antagonizes Inhibitor of apoptosis protein (IAP) family proteins, potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 29807457).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03166631 Phase I BI 754091 + BI 891065 BI 891065 A Trial to Find the Safe Dose for BI 891065 Alone and in Combination With BI 754091 in Patients With Incurable Tumours or Tumours That Have Spread Recruiting