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|Therapy Name||Cetuximab + Lumretuzumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cetuximab||Erbitux||IMC-C225||EGFR Antibody 29||Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR positive colorectal cancer (FDA.gov).|
|Lumretuzumab||RG7116|RO5479599||HER3 (ERBB3) Antibody 14||Lumretuzumab (RO5479599) is a humanized anti-Her3 (ERBB3) antibody that binds to and inhibits human epidermal growth factor receptor signaling, leading to growth inhibition in tumors (PMID: 26463709, PMID: 31423336).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Cetuximab + Lumretuzumab||Phase Ib/II||Actionable||In a Phase Ib trial, treatment with the combination of Erbitux (cetuximab) and Lumretuzumab demonstrated minimal clinical efficacy in ERBB3 (HER3)-positive advanced solid tumor patients, resulting in an objective response rate of 6.1% (3/49), including two partial responses and a complete response in one patient with squamous cell carcinoma of the head and neck (PMID: 28600476).||28600476|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|