Therapy Detail

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Therapy Name Tivantinib
Synonyms
Therapy Description

Tivantinib (ARQ197) is a selective MET inhibitor, which may induce cell death in tumor cells overexpressing MET, although the antimitotic effect may be more responsible for the anti-tumor activity (PMID: 28246274).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tivantinib ARQ197|ARQ 197|ARQ-197 MET Inhibitor 53 Tivantinib (ARQ197) is a selective MET inhibitor, which may induce cell death in tumor cells overexpressing MET, although the antimitotic effect may be more responsible for the anti-tumor activity (PMID: 28246274, PMID: 32569187, PMID: 32073648).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown multiple myeloma no benefit Tivantinib Phase II Actionable In a Phase II trial, Tivantinib (ARQ197) treatment only resulted in stable disease in 36% (4/11) of patients with relapsed or refractory multiple myeloma (PMID: 28337527). 28337527
Unknown unknown stomach carcinoma not applicable Tivantinib Phase II Actionable In a Phase II trial, Tivantinib (ARQ197) demonstrated efficacy in previously treated patients with metastatic gastric cancer (PMID: 24337769). 24337769
Unknown unknown Advanced Solid Tumor not applicable Tivantinib Phase I Actionable In a Phase I trial, Tivantinib (ARQ 197) demonstrated safety and some anti-tumor activity in patients with advanced solid tumors (PMID: 21976535). 21976535
Unknown unknown alveolar soft part sarcoma not applicable Tivantinib Phase II Actionable In a Phase II trial, tivantinib resulted in modest activity, in which 27 patients with alveolar soft part sarcoma had a median PFS of 5.5 months (PMID: 22605650). 22605650
Unknown unknown renal cell carcinoma not applicable Tivantinib Phase II Actionable In a Phase II trial, tivantinib resulted in modest activity in which six patients with renal cell carcinoma had a median PFS of 1.9 months (PMID: 22605650). 22605650
Unknown unknown clear cell sarcoma not applicable Tivantinib Phase II Actionable In a Phase II trial, tivantinib resulted in modest activity, in which 11 patients with clear cell sarcoma had a median PFS of 1.9 months (PMID: 22605650). 22605650

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02150733 Phase I Tivantinib Pharmacokinetics of Tivantinib in Subjects With Advanced Solid Tumors and Hepatic Impairment Completed USA 0
NCT01468922 Phase I Tivantinib Pazopanib Pazopanib and ARQ 197 for Advanced Solid Tumors Completed USA 0
NCT01755767 Phase III Tivantinib Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma Who Have Been Treated With One Prior Therapy Completed USA | CAN 14


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