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|Therapy Name||Radiotherapy + TAK-243|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|TAK-243||MLN7243||TAK-243 (MLN7243) is an inhibitor that selectively targets the ubiquitin activating enzyme, UBA1, which may result in inhibition of ubiquitination related processes such as cell cycle progression, apoptotic regulation, and DNA damage response (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A164).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Radiotherapy + TAK-243||Preclinical - Cell culture||Actionable||In a preclinical study, the combination of TAK-243 (MLN7243) and radiotherapy resulted in elevated levels of DNA damage and growth inhibition in cancer cell lines in vitro (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A164).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|