Therapy Detail

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Therapy Name BJ-1301
Synonyms
Therapy Description

BJ-1301 is a synthetic analogue of alpha-tocopherol that inhibits NADPH oxidase, which subsequently leads to inhibition of receptor tyrosine kinase signaling, resulting in decreased cell proliferation and reduced tumor growth (PMID: 28536313).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BJ-1301 BJ-1301 is a synthetic analogue of alpha-tocopherol that inhibits NADPH oxidase, which subsequently leads to inhibition of receptor tyrosine kinase signaling, resulting in decreased cell proliferation and reduced tumor growth (PMID: 28536313).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung non-small cell carcinoma not applicable BJ-1301 Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with BJ-1301 resulted in decreased cell proliferation and inhibited phosphorylation of molecules involved in PI3K/Akt and Ras/Erk signaling in non-small cell lung carcinoma (NSCLC) cells in culture, and repressed tumor growth in NSCLC cell line xenograft models (PMID: 28536313). 28536313

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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