Therapy Detail

Therapy Name Epacadostat + INCB001158
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Epacadostat INCB024360 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 20197554).
INCB001158 CB-1158 INCB001158 (CB-1158) is a human arginase inhibitor that restores arginine levels in T-cells, thereby promoting T-cell proliferation and anti-tumor immunity (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03361228 Phase Ib/II Epacadostat + INCB001158 Epacadostat + INCB001158 + Pembrolizumab A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid Tumors Completed