Therapy Detail
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| Therapy Name | Nivolumab + Pepinemab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Nivolumab | Opdivo | MDX-1106|BMS-936558 | Immune Checkpoint Inhibitor 135 PD-L1/PD-1 antibody 79 | Opdivo (nivolumab) is an antibody that targets PD-1 (PDCD1), which results in increased T-cell activation and enhanced anti-tumor immune response (PMID: 28891423). Opdivo (nivolumab) is FDA approved for use as a monotherapy in patients with non-small cell lung cancer, small cell lung cancer, Hodgkin's lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma, esophageal squamous cell carcinoma, resected esophageal or gastroesophageal junction (GEJ) cancer, as a monotherapy or in combination with Yervoy (ipilimumab) in patients with melanoma, renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (including patients 12 years or older), and hepatocellular carcinoma, in combination with Yervoy (ipilimumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, in combination with Yervoy (ipilimumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations, in combination with Cabometyx (cabozantinib) in patients with advanced renal cell carcinoma, and in combination with fluoropyrimidine- and platinum-containing chemotherapy in patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (FDA.gov). |
| Pepinemab | VX15/2503 | Pepinemab (VX15/2503) is a monoclonal antibody that binds to semaphorin 4D (SEMA4D) and blocks plexin-B1 binding, leading to anti-tumor and immune regulatory activity (PMID: 26446947, PMID: 28642891). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03425461 | Phase I | Ipilimumab + Pepinemab Nivolumab + Pepinemab | Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma | Terminated | USA | 0 |
| NCT03769155 | Phase I | Nivolumab + Pepinemab Ipilimumab + Pepinemab Pepinemab Ipilimumab + Nivolumab + Pepinemab | VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma | Recruiting | USA | 0 |
| NCT03373188 | Phase I | Nivolumab + Pepinemab Ipilimumab + Pepinemab Pepinemab | VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer | Recruiting | USA | 0 |
| NCT03690986 | Phase I | Ipilimumab Nivolumab Ipilimumab + Pepinemab Nivolumab + Pepinemab Pepinemab | VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer | Recruiting | USA | 0 |
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