Therapy Detail

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Therapy Name Roniciclib
Synonyms
Therapy Description

Roniciclib (BAY1000394) is a pan-CDK inhibitor that induces cell-cycle arrest and apoptosis, resulting in inhibition of tumor cell growth (PMID: 22821149).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Roniciclib BAY1000394|BAY10-00394|BAY 10-00394 CDK Inhibitor (Pan) 3 Roniciclib (BAY1000394) is a pan-CDK inhibitor that induces cell-cycle arrest and apoptosis, resulting in inhibition of tumor cell growth (PMID: 22821149, PMID: 30677506).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovarian cancer not applicable Roniciclib Phase I Actionable In a Phase I trial, treatment with Roniciclib (BAY 1000394) at the RP2D reduced PCNA expression and resulted in a disease control rate of 40.9% (n=22) in patients with ovarian cancer (PMID: 28463960; NCT01188252). 28463960
Unknown unknown Advanced Solid Tumor not applicable Roniciclib Phase I Actionable In a Phase I trial, treatment with Roniciclib (BAY 1000394) on a 3 days on/4 days off dosing schedule demonstrated safety and resulted in a disease control rate of 32.7% (34/104), with a response rate of 1% (1/104; 1 partial response) and stable disease in 31.7% (33/104) of patients with advanced solid tumors (PMID: 28463960; NCT01188252). detail... 28463960
Unknown unknown lung small cell carcinoma not applicable Roniciclib Phase I Actionable In a Phase I trial, treatment with Roniciclib (BAY 1000394) at the RP2D reduced PCNA expression and resulted in a disease control rate of 17.4% (n=23) in patients with small cell lung cancer (PMID: 28463960; NCT01188252). 28463960

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02161419 Phase II Roniciclib RONICICLIB / Placebo in Combination With Chemotherapy in Small Cell Lung Cancer Terminated
NCT02457351 Phase I Roniciclib Itraconazole Roniciclib (BAY 1000394) Drug-Drug Interaction (DDI) Study Completed
NCT02656849 Phase II Roniciclib BAY 1000394 for MCL-1-, MYC-, and CCNE1-Amplified Tumors Withdrawn


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