Therapy Detail

Therapy Name JNJ-63723283
Synonym
Therapy Description

JNJ-63723283 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JNJ-63723283 Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 50 JNJ-63723283 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable JNJ-63723283 Phase Ib/II Actionable In a Phase I/II trial, JNJ-63723283 demonstrated safety and preliminary efficacy, resulted in partial response in 9.4% (3/32) and stable disease in 56.3% (18/32) of patients with advanced solid tumors (Journal of Clinical Oncology 36, no. 5_suppl (February 10 2018) 58-58). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02908906 Phase I JNJ-63723283 A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers Recruiting