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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|JNJ-63723283||Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 62||JNJ-63723283 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||JNJ-63723283||Phase Ib/II||Actionable||In a Phase I/II trial, JNJ-63723283 demonstrated safety and preliminary efficacy, resulted in partial response in 9.4% (3/32) and stable disease in 56.3% (18/32) of patients with advanced solid tumors (Journal of Clinical Oncology 36, no. 5_suppl (February 10 2018) 58-58).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02908906||Phase I||JNJ-63723283||A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers||Active, not recruiting|