Therapy Detail

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Therapy Name ME-401
Synonyms
Therapy Description

ME-401 is a selective Pi3kd inhibitor that inhibits PI3K/AKT pathway signaling to decrease cell proliferation and induce cell death (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ME-401 ME401|PWT-143|PWT143 PIK3CD inhibitor 25 ME-401 is a selective Pi3kd inhibitor that inhibits PI3K/AKT pathway signaling to decrease cell proliferation and induce cell death (PMID: 31506873).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown CLL/SLL not applicable ME-401 Phase I Actionable In a Phase I trial, ME-401 treatment was well-tolerated, resulted in an objective response rate of 89% (9/10) in patients with relapsed or refractory CLL/SLL (J Clin Oncol 38: 2020 (suppl; abstr 8016); NCT02914938). detail...
Unknown unknown follicular lymphoma not applicable ME-401 Phase I Actionable In a Phase I trial, ME-401 treatment was well-tolerated, resulted in an objective response rate of 83% (29/35) in patients with relapsed or refractory follicular lymphoma (J Clin Oncol 38: 2020 (suppl; abstr 8016); NCT02914938). detail...
Unknown unknown marginal zone B-cell lymphoma not applicable ME-401 Phase I Actionable In a Phase I trial, ME-401 treatment was well-tolerated, resulted in an objective response rate of 100% (4/4) in patients with relapsed or refractory marginal zone B-cell lymphoma (J Clin Oncol 38: 2020 (suppl; abstr 8016); NCT02914938). detail...
Unknown unknown diffuse large B-cell lymphoma not applicable ME-401 Phase I Actionable In a Phase I trial, ME-401 treatment was well-tolerated, resulted in an objective response rate of 25% (2/8) in patients with relapsed or refractory diffuse large B-cell lymphoma (J Clin Oncol 38: 2020 (suppl; abstr 8016); NCT02914938). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status
NCT03768505 Phase II ME-401 Study of ME-401 in Subjects With Follicular Lymphoma After Failure of Two or More Prior Systemic Therapies Recruiting
NCT02914938 Phase I ME-401 ME-401 + Rituximab A Study of ME-401 in Subjects With CLL/SLL, FL, and B-cell Non Hodgkin's Lymphoma Recruiting


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