Therapy Detail
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| Therapy Name | Ladiratuzumab vedotin + Pembrolizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Ladiratuzumab vedotin | SGN-LIV1A | Ladiratuzumab vedotin (SGN-LIV1A) is a conjugate of anti-zinc transporter LIV-1 antibody and monomethyl auristatin E (MMAE), which delivers the cytotoxic agent to LIV1-positive cells, resulting in antitumor activity (PMID: 25253783). | ||
| Pembrolizumab | Keytruda | MK-3475 | Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 63 | Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, primary mediastinal large B-cell lymphoma, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous squamous cell carcinoma, MSI-H or dMMR or TMB high advanced solid tumors, PD-L1 expressing NSCLC, gastric and GEJ adenocarcinoma, squamous esophageal carcinoma, and cervical cancer, in combination with pemetrexed and platinum in non-squamous NSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in squamous NSCLC, with axitinib in RCC, and with Lenvatinib in endometrial carcinoma that is not MSI-H or dMMR (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT03310957 | Phase Ib/II | Ladiratuzumab vedotin + Pembrolizumab | Safety and Efficacy of SGN-LIV1A Plus Pembrolizumab for Patients With Locally-Advanced or Metastatic Triple-Negative Breast Cancer | Recruiting |
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