Therapy Detail

Therapy Name BMS-536924
Synonym
Therapy Description

BMS-536924 is an ATP-competitive inhibitor of IGF-1R and IR, which induces tumor cell apoptosis and decreases tumor growth (PMID: 25897243).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BMS-536924 IGF-1R Inhibitor 17 BMS-536924 is an ATP-competitive inhibitor of IGF-1R and IR, which induces tumor cell apoptosis and decreases tumor growth (PMID: 25897243).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6-NTRK3 Advanced Solid Tumor sensitive BMS-536924 Preclinical Actionable In a preclinical study, transformed human cells expressing ETV6-NTRK3 were sensitive to BMS-536924, demonstrating a reduction in both cell survival and transformation activity in culture (PMID: 21804605). 21804605
Clinical Trial Phase Therapies Title Recruitment Status