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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DS-6051a||ROS1 Inhibitor 14 Trk Receptor Inhibitor (Pan) 23||DS-6051a is the free base form of DS-6051b that inhibits ROS1 and NTRK1/2/3, which may lead to growth inhibition in tumor cells (PMID: 27477320).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - NTRK3||melanoma||sensitive||DS-6051a||Preclinical - Cell culture||Actionable||In a preclinical study, DS-6051a inhibited MAPK, PI3K, and PLCgamma-1 signaling in transformed melanocytes expressing ETV6-NTRK3 in culture (PMID: 27477320).||27477320|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|