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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|COTI-2||COTI2||p53 Activator 10||COTI-2 is a small molecule that targets mutant Tp53 and potentially inhibits tumor cell growth, alone or in combination with other agents (PMID: 28756138, PMID: 27150056, PMID: 29364966).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02433626||Phase I||COTI-2 Cisplatin + COTI-2||Study of COTI-2 as Monotherapy or Combination Therapy for the Treatment of Malignancies (COTI2-101)||Recruiting|