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TAS6417 is a small molecule that inhibits EGFR and has selectivity for EGFR mutations including exon 20 insertions, resulting in decreased EGFR signaling and potentially leading to decreased growth of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CLN-081||TAS6417|TAS-6417|CLN 081|CLN081||EGFR Inhibitor (Pan) 47||CLN-081 (TAS6417) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT04036682||Phase Ib/II||CLN-081||A Phase 1/2a Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer||Recruiting|