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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DM-CHOC-PEN||4-Demethyl-4-cholesteryloxycarbonylpenclomedine||DM-CHOC-PEN (4-Demethyl-4-cholesteryloxycarbonylpenclomedine) is a carbonate derivative of 4-demethylpenclomedine that alkylates DNA, resulting in cell death (PMID: 19255760, PMID: 26186448).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||DM-CHOC-PEN||Phase I||Actionable||In a Phase I trial, DM-CHOC-PEN (4-Demethyl-4-cholesteryloxycarbonylpenclomedine) treatment resulted in complete/partial response in 25% (3/12) of adolescent and young adult patients with advanced solid tumors (non-small cell lung cancer, acute lymphocytic leukemia, astrocytoma), improved quality of life, progression-free survival, and overall survival of 8-26 months (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A086; NCT02889445).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03668847||Phase II||DM-CHOC-PEN||DM-CHOC-PEN for Brain Tumors in AYA Subjects||Recruiting||USA||0|
|NCT03371004||Phase I||DM-CHOC-PEN||DM-CHOC-PEN Plus Radiation for Brain Tumors||Recruiting||USA||0|
|NCT02889445||Expanded access||DM-CHOC-PEN||A Phase I Trial of DM-CHOC-PEN in Adolescent and Young Adult (AYA) Subjects With Advanced Cancers||No longer available||USA||0|