Therapy Detail

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Therapy Name DM-CHOC-PEN
Synonyms
Therapy Description

DM-CHOC-PEN (4-Demethyl-4-cholesteryloxycarbonylpenclomedine) is a carbonate derivative of 4-demethylpenclomedine that alkylates DNA, resulting in cell death (PMID: 19255760).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DM-CHOC-PEN 4-Demethyl-4-cholesteryloxycarbonylpenclomedine DM-CHOC-PEN (4-Demethyl-4-cholesteryloxycarbonylpenclomedine) is a carbonate derivative of 4-demethylpenclomedine that alkylates DNA, resulting in cell death (PMID: 19255760, PMID: 26186448).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable DM-CHOC-PEN Phase I Actionable In a Phase I trial, DM-CHOC-PEN (4-Demethyl-4-cholesteryloxycarbonylpenclomedine) treatment resulted in complete/partial response in 25% (3/12) of adolescent and young adult patients with advanced solid tumors (non-small cell lung cancer, acute lymphocytic leukemia, astrocytoma), improved quality of life, progression-free survival, and overall survival of 8-26 months (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A086; NCT02889445). detail...

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  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03668847 Phase II DM-CHOC-PEN DM-CHOC-PEN for Brain Tumors in AYA Subjects Recruiting USA 0
NCT03371004 Phase I DM-CHOC-PEN DM-CHOC-PEN Plus Radiation for Brain Tumors Recruiting USA 0
NCT02889445 Expanded access DM-CHOC-PEN A Phase I Trial of DM-CHOC-PEN in Adolescent and Young Adult (AYA) Subjects With Advanced Cancers No longer available USA 0


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