Therapy Detail

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Therapy Name AZD1390
Synonyms
Therapy Description

AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZD1390 AZD 1390|AZD-1390 ATM Inhibitor 13 AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant glioblastoma sensitive AZD1390 Preclinical - Cell culture Actionable In a preclinical study, TP53 mutant glioblastoma cells demonstrated increased sensitivity to radiosensitization by AZD1390 treatment compared to TP53 wild-type cells in culture (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). detail...
ATM positive glioblastoma sensitive AZD1390 Preclinical - Cell line xenograft Actionable In a preclinical study, AZD1390 inhibited Atm activity, sensitized glioblastoma cell lines to radiotherapy in culture, and demonstrated efficacy in mouse models of glioblastoma (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). detail...
ATM positive lung cancer sensitive AZD1390 Preclinical - Cell line xenograft Actionable In a preclinical study, AZD1390 inhibited Atm activity, sensitized lung cancer cells to radiotherapy in culture, and demonstrated efficacy in cell line xenograft models (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). detail...

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05678010 Phase I AZD1390 A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer Recruiting USA 0
NCT04550104 Phase I AZD1390 Olaparib A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC (CONCORDE) Recruiting GBR 0
NCT05182905 Phase I AZD1390 Phase 0 Plus Expansion Study of AZD1390 in Recurrent GBM Patients Recruiting USA 0
NCT03423628 Phase I AZD1390 A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer Recruiting USA | GBR 0


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