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Therapy Name GB226
Synonyms
Therapy Description

Geptanolimab (GB226) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 29932513, PMID: 33046518).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GB226 Geptanolimab|GB-226|GB 226|CBT501|CBT-501|Genolimzumab Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 Geptanolimab (GB226) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 29932513, PMID: 33046518).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive alveolar soft part sarcoma not predictive GB226 Phase II Actionable In a Phase II trial (Gxplore-005), patients with CD274 (PD-L1)-positive (CPS >=1%) alveolar soft part sarcoma achieved an objective response rate (ORR) of 33.3% (4/12; 95% CI 9.9-65.1) and a disease control rate (DCR) of 83.3% (10/12; 95% CI 51.6-97.9) in response to Geptanolimab (GB226) treatment, which were not different from the 40.0% ORR (10/25; 95% CI 21.1-61.3) and 88.0% DCR (22/25; 95% CI 68.8-97.5) observed in CD274 (PD-L1)-negative (CPS <1%) patients (PMID: 33046518; NCT03623581). 33046518

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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