Therapy Detail

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Therapy Name Loncastuximab tesirine-lpyl
Synonyms
Therapy Description

Zynlonta (loncastuximab tesirine-lpyl) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214). Zynlonta (loncastuximab tesirine-lpyl) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Loncastuximab tesirine-lpyl Zynlonta ADCT-402 CD19 Antibody 20 Zynlonta (loncastuximab tesirine-lpyl) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214). Zynlonta (loncastuximab tesirine-lpyl) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05660395 Phase I Loncastuximab tesirine-lpyl A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10) Recruiting USA 3
NCT05453396 Phase II Loncastuximab tesirine-lpyl Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies Recruiting USA 0
NCT05464719 Phase II Loncastuximab tesirine-lpyl A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy Recruiting USA 0
NCT04699461 Phase II Idelalisib Loncastuximab tesirine-lpyl Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine Versus Idelalisib in Participants With Relapsed or Refractory Follicular Lymphoma (LOTIS 6) Terminated USA | ITA | GBR | FRA | ESP | BEL 4
NCT03589469 Phase II Loncastuximab tesirine-lpyl Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma Completed USA | ITA | GBR 1
NCT05249959 Phase II Bendamustine + Cytarabine + Rituximab Loncastuximab tesirine-lpyl Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients. (FIL_COLUMN) Recruiting ITA 0


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