Therapy Name | IT-141 |
Therapy Description |
IT-141 is composed of a polymer micelle, ITP-101, which contains the hydrophobic drug, SN-38, allowing greater solubility and potentially resulting in antitumor activity (PMID: 22187652). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
IT-141 | IT-141 is composed of a polymer micelle, ITP-101, which contains the hydrophobic drug, SN-38, allowing greater solubility and potentially resulting in antitumor activity (PMID: 22187652). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | Unknown unknown | colon cancer | not applicable | IT-141 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, colon cancer cell line xenograft models demonstrated tumor regression when treated with IT-141 (PMID: 22187652). | 22187652 |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status |
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NCT03096340 | Phase I | IT-141 | Safety and Pharmacokinetic Study of IT-141 in Monotherapy in Patients With Advanced Cancer | Recruiting |