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Therapy Name PVSRIPO
Synonyms
Therapy Description

PVSRIPO is an oncolytic virus comprising a recombinant poliovirus/rhinovirus chimera, which targets CD155 (Necl5)-expressing tumor cells, and potentially induces enhanced anti-tumor immune response and tumor cell cytotoxicity (PMID: 21984883, PMID: 24939611).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PVSRIPO PVS-RIPO|NSC-719277|NSC719277 PVSRIPO is an oncolytic virus comprising a recombinant poliovirus/rhinovirus chimera, which targets CD155 (Necl5)-expressing tumor cells, and potentially induces enhanced anti-tumor immune response and tumor cell cytotoxicity (PMID: 21984883, PMID: 24939611).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04577807 Phase II PVSRIPO + unspecified PD-1 antibody PVSRIPO PVSRIPO With or Without Immune Checkpoint Blockade in Patients With Advanced PD-1 Refractory Melanoma Active, not recruiting USA 0
NCT02986178 Phase II Lomustine + PVSRIPO PVSRIPO PVSRIPO With/Without Lomustine Active, not recruiting USA 0
NCT03564782 Phase I PVSRIPO Examining Bioactivity of PVSRIPO in Invasive Breast Cancer Completed USA 0
NCT03712358 Phase I PVSRIPO PVSRIPO for Patients With Unresectable Melanoma Completed USA 0
NCT04599647 Expanded access PVSRIPO EAP for the Treatment of Glioblastoma With PVSRIPO No longer available USA 0


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