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Genistein binds to protein tyrosine kinase, inhibiting downstream signaling and promoting differentiation, and also inhibits topoisomerase leading to cell cycle arrest and apoptosis (NCI Drug Dictionary).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Genistein||CI 75610|Prunetol|Genisteol||Genistein binds to protein tyrosine kinase, inhibiting downstream signaling and promoting differentiation, and also inhibits topoisomerase leading to cell cycle arrest and apoptosis (PMID: 32486630).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT01489813||Phase II||Genistein||Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment||Recruiting||USA||0|
|NCT02624388||Phase II||Genistein||Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)||Unknown status||USA||0|
|NCT02766478||Phase II||Genistein||Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer||Suspended||USA||0|
|NCT01985763||Phase Ib/II||Genistein Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab||Genistein in Treatment of Metastatic Colorectal Cancer||Completed||USA||0|