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Therapy Name GSK3359609 + Tremelimumab
Synonyms
Therapy Description

GSK3359609 is an antibody that binds to the inducible T-cell co-stimulator, resulting in stimulation of T-cell proliferation and immune response (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GSK3359609 GSK609|GSK-3359609|GSK 3359609|feladilimab GSK3359609 is an antibody that binds to the inducible T-cell co-stimulator (ICOS, CD278), resulting in stimulation of T-cell proliferation and immune response (AACR Annual Meeting 2019, Abstract CT166, PMID: 31847708).
Tremelimumab Imjudo CP-675,206|Ticilimumab|CP-675206 CTLA4 Antibody 29 Immune Checkpoint Inhibitor 147 Imjudo (tremelimumab) binds to and inhibits cytotoxic T-lymphocyte-associated protein 4 (CTLA4), thereby enhancing T-cell activation by blocking CTLA4-mediated inhibition of T-cell activation (PMID: 32620213, PMID: 32586937). Imjudo (tremelimumab) is FDA approved for use in combination with Imfinzi (durvalumab) in adult patients with unresectable hepatocellular carcinoma, and in combination with Imfinzi (durvalumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03693612 Phase Ib/II GSK3359609 + Tremelimumab Paclitaxel Docetaxel Cetuximab GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors Completed USA | CAN | AUS 0


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