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|Therapy Name||Dexamethasone + Nab-rapamycin + Pomalidomide|
Nab-Rapamycin is nanoparticle albumin-bound rapamycin that has immunosuppressant and anti-tumor activities (PMID: 24089446).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Nab-rapamycin||Fyarro||ABI-009|nab-sirolimus||mTORC1 Inhibitor 9||Fyarro (nab-rapamycin) is nanoparticle albumin-bound rapamycin and inhibitor of mTOR that has immunosuppressant and anti-tumor activities (PMID: 24089446). Fyarro (nab-rapamycin) is FDA approved for use in patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (FDA.gov).|
|Pomalidomide||Pomalyst||CC-4047||Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03657420||Phase I||Dexamethasone + Nab-rapamycin + Pomalidomide||Safety and Efficacy of ABI-009 (Nab-rapamycin) in Combination With Pomalidomide and Dexamethasone for Relapsed and Refractory Multiple Myeloma||Withdrawn||USA||0|