Therapy Detail

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Therapy Name EGFR806-specific CAR T cells
Synonyms
Therapy Description

EGFR806-specific CAR T cells are autologous T-cells engineered with a lentiviral vector to express a chimeric antigen receptor that targets EGFR present in abnormal conformational states, including EGFRvIII and other activating mutants, which result in enhanced anti-tumor response against EGFR-expressing tumors (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EGFR806-specific CAR T cells autologous CD4+/CD8+ T cells expressing EGFR806-specific CAR/EGFRt EGFR Immune Cell Therapy 3 EGFR806-specific CAR T cells are autologous T-cells engineered with a lentiviral vector to express a chimeric antigen receptor that targets EGFR present in abnormal conformational states, including EGFRvIII and other activating mutants, which result in enhanced anti-tumor response against EGFR-expressing tumors (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03638167 Phase I EGFR806-specific CAR T cells EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors Recruiting USA 0


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