Therapy Detail

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Therapy Name Milatuzumab
Synonyms
Therapy Description

Milatuzumab (IMMU-115) is a monocloncal antibody to CD74 that induces apoptosis and targets tumor cells with high CD74 expression, such as B-cells (PMID: 25754579, PMID: 28466956).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Milatuzumab IMMU-115|hLL1 CD74 Antibody 3 Milatuzumab (IMMU-115) is a monocloncal antibody to CD74 that induces apoptosis and targets tumor cells with high CD74 expression, such as B-cells (PMID: 25754579, PMID: 28466956).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown chronic lymphocytic leukemia not applicable Milatuzumab Phase Ib/II Actionable In a Phase Ib/II trial, Milatuzumab (hLL1) treatment of elderly and refractory chronic lymphocytic leukemia patients resulted in one patient (12.5%, 1/8) with an ongoing response at 18-months (PMID: 28466956). 28466956
Unknown unknown hematologic cancer no benefit Milatuzumab Phase I Actionable In a Phase I trial, Milatuzumab (hLL1) treatment of a mixed cohort of B-cell malignancies patients, resulted in stable disease in 35% (8/23), but there was no evidence of tumor shrinkage (PMID: 25754579). 25754579

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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