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Therapy Name MEDI1873
Synonyms
Therapy Description

MEDI1873 is a glucocorticoid-induced tumor necrosis factor related-protein (GITR) agonist that is comprised of an IgG1 Fc domain, coronin 1A trimerization domain, and a GITRL extracellular domain, which when administered may lead to T-cell activation, thereby promoting antitumor immunity (PMID: 28405505).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MEDI1873 MEDI1873 is a glucocorticoid-induced tumor necrosis factor related-protein (GITR) agonist that is comprised of an IgG1 Fc domain, coronin 1A trimerization domain, and a GITRL extracellular domain, which when administered may lead to T-cell activation, thereby promoting antitumor immunity (PMID: 28405505).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable MEDI1873 Phase I Actionable In a Phase I trial, patients with either non-small cell lung carcinoma, head and neck squamous cell carcinoma, or colorectal cancer demonstrated a best overall response of stable disease in 42.5% (17/40) and stable disease for 24 weeks or more in 17.5% (7/40) and 52.5 weeks or more in 7.5% (3/40) when treated with MEDI1873 (Annals of Oncology (2018) 29 (suppl_8); NCT02583165). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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