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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NEO214||NEO214 is a conjugate of the phosphodiesterase 4 inhibitor rolipram and perillyl alcohol, which may induce ER-stress related apoptosis in tumor cells and decrease tumor growth (PMID: 30647121).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||malignant glioma||not applicable||NEO214||Preclinical||Actionable||In a preclinical study, NEO214 induced apoptosis and inhibited growth of glioma cell lines in culture, including cell lines resistant to Temodar (temozolmide), and inhibited tumor growth and improved survival in a mouse glioma model (PMID: 30647121).||30647121|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|