Therapy Detail

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Therapy Name MK-8353 + Selumetinib
Synonyms
Therapy Description

Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MK-8353 SCH900353 ERK Inhibitor (pan) 21 MK-8353 is an analog of SCH772984, which targets both Erk1 and Erk2 and may inhibit cell growth (PMID: 25142146, PMID: 29467321).
Selumetinib Koselugo AZD6244|ARRY-142886 MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24 Koselugo (selumetinib) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210). Koselugo (selumetinib) is FDA approved for use in pediatric patients of 2 years or older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03745989 Phase I MK-8353 + Selumetinib Study of MK-8353 + Selumetinib in Advanced/Metastatic Solid Tumors (MK-8353-014) Completed USA | CAN 1


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