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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LY2780301||Akt Inhibitor (Pan) 18 S6 Kinase Inhibitor 5||LY2780301 is an inhibitor of AKT and P70S6 kinases, which prevents signaling of the PI3K/AKT pathway thereby possibly resulting in antitumor activity (PMID: 25902900, PMID: 28877935).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||LY2780301||Phase I||Actionable||In a Phase I trial, LY2780301 demonstrated safety and preliminary efficacy in patients with a variety of advanced solid tumors (PMID: 25902900).||25902900|
|PIK3CA E545K||colon cancer||sensitive||LY2780301||Phase I||Actionable||In a Phase I trial, a colon cancer patient harboring PIK3CA E545K was sensitive to LY2780301, demonstrating stable disease for approximately 125 days (PMID: 25902900).||25902900|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|