Therapy Detail
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| Therapy Name | Carboplatin + INCMGA00012 + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 6 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| INCMGA00012 | MGA 012|Retifanlimab | Immune Checkpoint Inhibitor 95 PD-L1/PD-1 antibody 63 | INCMGA00012 is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085). | |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 12 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT03920839 | Phase I | Carboplatin + INCMGA00012 + Paclitaxel Cisplatin + Gemcitabine + INCMGA00012 Cisplatin + INCMGA00012 + Pemetrexed Disodium Carboplatin + INCMGA00012 + Pemetrexed Disodium | INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105) | Withdrawn |
| NCT04205812 | Phase III | INCMGA00012 Pemetrexed Disodium Carboplatin + Nab-paclitaxel Cisplatin + Pemetrexed Disodium Carboplatin + INCMGA00012 + Pemetrexed Disodium Carboplatin + INCMGA00012 + Nab-paclitaxel Cisplatin + INCMGA00012 + Pemetrexed Disodium INCMGA00012 + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium Carboplatin + INCMGA00012 + Paclitaxel Carboplatin + Paclitaxel | Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer (POD1UM-304) | Recruiting |
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