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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Navitoclax||ABT-263||BCL-XL inhibitor 11 BCL2 inhibitor 17||Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766, PMID: 32513939).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Navitoclax||Preclinical - Cell culture||Actionable||In a preclinical study, Navitoclax (ABT-263) treatment alone was not effective in a number of cell lines derived from solid tumors in culture (PMID: 27974663).||27974663|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03592576||Expanded access||Navitoclax||Expanded Access to Navitoclax||Available|
|NCT04041050||Navitoclax Ruxolitinib||A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Alone and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm||Recruiting|