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Therapy Name | Durvalumab + MEDI1191 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Durvalumab | Imfinzi | MEDI4736 | Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 86 | Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, and in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer (FDA.gov). |
MEDI1191 | MEDI-1191 | MEDI1191 is an encapsulated mRNA formulation of interleukin-12 subunit beta (IL12B) and interleukin-12 subunit alpha (IL12A), which activate the immune system and prevent tumor cell proliferation (PMID: 32817076). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03946800 | Phase I | MEDI1191 Durvalumab + MEDI1191 | A Study of MEDI1191 Alone and in Combination With Durvalumab in Subjects With Advanced Solid Tumors | Recruiting | USA | FRA | ESP | 1 |