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|Therapy Name||Cyclophosphamide + iCasp9M28z T cells|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cyclophosphamide||Cytoxan||CPM||Chemotherapy - Alkylating 14||Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).|
|iCasp9M28z T cells||anti-mesothelin iCasp9M28z||iCasp9M28z T cells are autologous T-cells that express a chimeric antigen receptor targeting mesothelin, which potentially enhances anti-tumor immune response against mesothelin-expressing tumor cells (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02414269||Phase I||Cyclophosphamide + iCasp9M28z T cells iCasp9M28z T cells||Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin||Recruiting|