Therapy Detail

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Therapy Name Sotorasib
Synonyms
Therapy Description

Sotorasib (AMG 510) is small molecule inhibitor that selectively targets KRAS G12C, which may result in inhibition of tumor growth (J Clin Oncol 37, 2019 (suppl; abstr 3003)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Sotorasib Lumakras AMG 510|AMG510|AMG-510 KRAS G12C inhibitor 25 Lumakras (sotorasib) is small molecule inhibitor that selectively targets KRAS G12C and inhibits downstream signaling, which may lead to growth inhibition of tumors harboring KRAS G12C (PMID: 31666701). Lumakras (sotorasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04667234 Expanded access Sotorasib Expanded Access of AMG 510 (pINN Sotorasib) Available USA 5
NCT04185883 Phase I Sotorasib AMG 510 (pINN) Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) Recruiting USA | ESP | DEU | CAN | BEL | AUT 3
NCT05398094 Phase II Sotorasib Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy (MERIT-lung) Recruiting ESP 0
NCT03600883 Phase Ib/II Sotorasib + unspecified PD-1 antibody Sotorasib + unspecified PD-L1 antibody Sotorasib A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreak 100) Recruiting USA | FRA | ESP | DEU | CAN | BEL | AUT 9
NCT04303780 Phase III Sotorasib Docetaxel Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200). Active, not recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 16
NCT04933695 Phase II Sotorasib A Study of Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment (CodeBreaK201) Active, not recruiting USA | ITA | FRA | ESP | DEU | BEL 4
NCT04625647 Phase II Sotorasib Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) Recruiting USA 1


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