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|Therapy Name||Canakinumab + Ieramilimab + Spartalizumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Canakinumab||Ilaris||ACZ-885||Ilaris (canakinumab) is a monoclonal antibody against interleukin-1beta, which has anti-inflammatory activity and may decrease tumor progression (PMID: 28855077).|
|Ieramilimab||LAG-525|LAG525|IMP-701||Immune Checkpoint Inhibitor 153 LAG3 Antibody 18||Ieramilimab (LAG525) is a monoclonal antibody that targets LAG3 and blocks interaction with MHC class II molecules, leading to enhanced T-cell response to tumor cells and decreased tumor growth (NCI Drug Dictionary).|
|Spartalizumab||PDR001|PDR-001||Immune Checkpoint Inhibitor 153 PD-L1/PD-1 antibody 100||Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32364844, PMID: 32179633).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03742349||Phase I||Canakinumab + Ieramilimab + Spartalizumab Ieramilimab + MCS110 + Spartalizumab Capmatinib + Ieramilimab + Spartalizumab Ieramilimab + Spartalizumab + Taminadenant||Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).||Terminated||USA | ITA | ESP||6|