Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MAP855||MEK inhibitor (Pan) 23||MAP855 is a selective ATP-competitive inhibitor of Mek, which may lead to inhibition of Erk signaling and cell growth (PMID: 29483135).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF K601E MAP2K1 V211D||colon cancer||sensitive||MAP855||Preclinical - Pdx||Actionable||In a preclinical study, MAP955 inhibited Rsk and Erk phosphorylation, and resulted in 30% tumor regression in patient-derived xenograft (PDX) models of metastatic colon cancer harboring BRAF K601E and MAP2K1 V211D (PMID: 31227518).||31227518|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|