Therapy Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Therapy Name Pelitinib
Synonyms
Therapy Description

Pelitinib is a nonselective inhibitor of EGFR, ERBB2 (HER2), and HER4, which induces apoptosis and inhibits cell proliferation (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
Pelitinib EKB-569|WAY-EKB 569 EGFR Inhibitor (Pan) 46 HER2 Inhibitor 23 Pelitinib (EKB-569) is a nonselective inhibitor of EGFR, ERBB2 (HER2), and ERBB4 (HER4), which induces apoptosis and inhibits cell proliferation (PMID: 25988710).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 L1157R cancer sensitive Pelitinib Preclinical - Cell culture Actionable In a preclinical study, Pelitinib inhibited growth of transformed cells expressing ERBB2 (HER2) L1157R in culture (PMID: 32366937). 32366937
ERBB2 P489L cancer sensitive Pelitinib Preclinical - Cell culture Actionable In a preclinical study, Pelitinib inhibited growth of transformed cells expressing ERBB2 (HER2) P489L in culture (PMID: 32366937). 32366937
ERBB2 R188C cancer sensitive Pelitinib Preclinical - Cell culture Actionable In a preclinical study, Pelitinib inhibited growth of transformed cells expressing ERBB2 (HER2) R188C in culture (PMID: 32366937). 32366937

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


Additional content available in CKB BOOST