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Therapy Name UNC0642
Synonyms
Therapy Description

UNC0642 (MP-IN-317) is a histone methyltransferase inhibitor that selectively inhibits EHMT2 (G9A) and GLP, which has potential cytotoxic effects against cancer cells (PMID: 24102134, PMID: 30712867).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
UNC0642 MP-IN-317 EHMT2 Inhibitor 4 UNC0642 (MP-IN-317) is a histone methyltransferase inhibitor that selectively inhibits EHMT2 (G9A) and EHMT1 (GLP), which may result in decreased methylation and potential cytotoxic effects against cancer cells (PMID: 24102134).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable UNC0642 Preclinical - Cell culture Actionable In a preclinical study, UNC0642 decreased H3K9me2 levels, but did not inhibit colony formation in a breast cancer cell line in culture (PMID: 24102134). 24102134
Unknown unknown pancreatic carcinoma not applicable UNC0642 Preclinical - Cell culture Actionable In a preclinical study, a pancreatic carcinoma cell line demonstrated sensitivity to UNC0642, resulting in inhibition of colony formation in culture (PMID: 24102134). 24102134

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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