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Therapy Name A-366
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
A-366 A-366 is a peptide drug that specifically inhibits G9a/GLP methyltransferase, which potentially results in reduced H3K9me2 levels and inhibits tumor growth (PMID: 26147105).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable A-366 Preclinical - Cell line xenograft Actionable In a preclinical study, A-366 inhibited proliferation and reduced cell viability in an acute myeloid leukemia (AML) cell line in culture, and inhibited tumor growth in an AML cell line xenograft model (PMID: 26147105). 26147105
Unknown unknown acute promyelocytic leukemia not applicable A-366 Preclinical - Cell culture Actionable In a preclinical study, A-366 inhibited cell proliferation and increased differentiation in an acute promyelocytic leukemia cell line in culture (PMID: 26147105). 26147105

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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