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Therapy Name | Minnelide |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Minnelide | Minnelide is a water-soluble prodrug of the naturally derived diterpene triepoxide, triptolide, which induces apoptosis and inhibits cell proliferation, leading to reduced tumor growth (PMID: 28192510, PMID: 32733649). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | gastric adenocarcinoma | not applicable | Minnelide | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Minnelide treatment inhibited tumor growth and induced regression in gastric adenocarcinoma cell line xenograft models (PMID: 28192510). | 28192510 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT03760523 | Phase I | Minnelide | Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia | Recruiting | USA | 0 |