Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SMI#9-GNP||SMI#9-GNP is comprised of the RAD6 inhibitor SMI#9 conjugated to gold nanoparticles (GNP), which potentially inhibits cell proliferation, colony formation, and tumor growth (PMID: 30242094).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||triple-receptor negative breast cancer||not applicable||SMI#9-GNP||Preclinical - Cell line xenograft||Actionable||In a preclinical study, SMI#9-GNP treatment inhibited proliferation, and colony formation, and induced apoptosis in triple-negative breast cancer cell lines harboring either wild-type or mutant BRCA1 in culture, and inhibited tumor growth in cell line xenograft models (PMID: 30242094).||30242094|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|