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Therapy Name | SMI#9-GNP |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
SMI#9-GNP | SMI#9-GNP is comprised of the RAD6 inhibitor SMI#9 conjugated to gold nanoparticles (GNP), which potentially inhibits cell proliferation, colony formation, and tumor growth (PMID: 30242094). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | triple-receptor negative breast cancer | not applicable | SMI#9-GNP | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMI#9-GNP treatment inhibited proliferation, and colony formation, and induced apoptosis in triple-negative breast cancer cell lines harboring either wild-type or mutant BRCA1 in culture, and inhibited tumor growth in cell line xenograft models (PMID: 30242094). | 30242094 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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