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|Therapy Name||Tamatinib + Tazemetostat|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Tamatinib||R406|R-406||SYK Inhibitor 14||Tamatinib (R406) inhibits SYK, resulting in decreased downstream signaling and and potentially leading to reduced tumor cell proliferation and viability (PMID: 16946104, PMID: 26251761, PMID: 30668583).|
|Tazemetostat||Tazverik||EPZ6438|E-7438|EPZ-6438||EZH2 inhibitor 18||Tazverik (tazemetostat) binds to and inhibits EZH2, resulting in decreased tri-methylation of H3K27, and potentially leading to inhibition of cell proliferation and tumor growth (PMID: 23620515). Tazverik (tazemetostat) is FDA approved for use in patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection, and in adult patients with relapsed or refractory follicular lymphoma (R/R FL) harboring an EZH2 mutation after 2 prior therapies, and in patients with R/R FL without treatment options (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EZH2 mutant||diffuse large B-cell lymphoma||sensitive||Tamatinib + Tazemetostat||Preclinical - Cell culture||Actionable||In a preclinical study, Tazemetostat (EPZ-6438) and Tamatinib (R406) synergistically inhibited proliferation of diffuse large B-cell lymphoma cell lines harboring EZH2 mutations in culture (PMID: 28835384).||28835384|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|